PLoS One:左心房体积与性别、BSA、糖尿病、肾功能和NT-proBNP水平相关

2016-10-30 MedSci MedSci原创

重要性:左心房(LA)扩大是卒中发生的重要危险因素,也是心房颤动(AF)患者心律控制策略成功的关键因素。然而,与房颤患者LA容量相关的因素知之甚少。方法:阵发性或持续性房颤的患者参加了这项研究。所有参与者行实时三维超声心动图检查,并以标准化的方式进行离线分析。研究者使用一组广泛的临床参数进行了逐步的向后线性回归分析,以确定与三维LA体积独立的相关的因素。结果:研究者纳入了210例患者(70.9%男

重要性:左心房(LA)扩大是卒中发生的重要危险因素,也是心房颤动(AF)患者心律控制策略成功的关键因素。然而,与房颤患者LA容量相关的因素知之甚少。

方法:阵发性或持续性房颤的患者参加了这项研究。所有参与者行实时三维超声心动图检查,并以标准化的方式进行离线分析。研究者使用一组广泛的临床参数进行了逐步的向后线性回归分析,以确定与三维LA体积独立的相关的因素。

结果:研究者纳入了210例患者(70.9%男性,平均年龄61±11岁)。阵发性和持续性房颤分别有95(45%)和115(55%)。总体而言,有115(55%)例患者有高血压,11(5%)例患者有糖尿病,18(9%)有缺血性心脏病。平均LA体积为36±12ml/m2。在多变量模型中,女性(β系数-10.51(95% CI:17.85;3.16),电复律(β11.95(5.15;18.74),糖尿病(β14.23(2.36;26.10),体表面积(BSA)(β34.21(19.30;49.12),肾小球滤过率(β-0.21(-0.36;- 0.06)及血浆NT-proBNP(β6.79( 4.05;9.52)与心房体积相关,而与年龄(P = 0.59)或高血压(P = 0.42)不相关。最终模型解释了52%的LA体积变化。

结论:在房颤患者中, LA体积与性别、BSA、糖尿病、肾功能和NT-proBNP水平相关,而不与年龄或高血压相关。这些结果可能有助于改善房颤患者的心律的控制策略。

原始出处:

Bossard M, Kreuzmann R, et al. Determinants of Left Atrial Volume in Patients with Atrial Fibrillation. PLoS One. 2016 Oct 4


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    2017-09-06 yese
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    2017-07-15 ylz8411
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    2016-11-01 huiwelcome
  5. [GetPortalCommentsPageByObjectIdResponse(id=1850589, encodeId=2d42185058919, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Wed Sep 06 14:04:00 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659697, encodeId=602c165969e70, content=<a href='/topic/show?id=da5c480e024' target=_blank style='color:#2F92EE;'>#左心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48070, encryptionId=da5c480e024, topicName=左心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50dc25016902, createdName=ylz8411, createdTime=Sat Jul 15 08:04:00 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789851, encodeId=1fd81e898515d, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Mon May 01 21:04:00 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289294, encodeId=789e1289294b9, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Tue Nov 01 04:04:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290333, encodeId=d408129033333, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Tue Nov 01 04:04:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601818, encodeId=d26516018182a, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Tue Nov 01 04:04:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626821, encodeId=1f541626821a2, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Nov 01 04:04:00 CST 2016, time=2016-11-01, status=1, ipAttribution=)]
    2016-11-01 mjldent
  6. [GetPortalCommentsPageByObjectIdResponse(id=1850589, encodeId=2d42185058919, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Wed Sep 06 14:04:00 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659697, encodeId=602c165969e70, content=<a href='/topic/show?id=da5c480e024' target=_blank style='color:#2F92EE;'>#左心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48070, encryptionId=da5c480e024, topicName=左心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50dc25016902, createdName=ylz8411, createdTime=Sat Jul 15 08:04:00 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789851, encodeId=1fd81e898515d, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Mon May 01 21:04:00 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289294, encodeId=789e1289294b9, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Tue Nov 01 04:04:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290333, encodeId=d408129033333, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Tue Nov 01 04:04:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601818, encodeId=d26516018182a, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Tue Nov 01 04:04:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626821, encodeId=1f541626821a2, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Nov 01 04:04:00 CST 2016, time=2016-11-01, status=1, ipAttribution=)]
    2016-11-01 sunylz
  7. [GetPortalCommentsPageByObjectIdResponse(id=1850589, encodeId=2d42185058919, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Wed Sep 06 14:04:00 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1659697, encodeId=602c165969e70, content=<a href='/topic/show?id=da5c480e024' target=_blank style='color:#2F92EE;'>#左心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48070, encryptionId=da5c480e024, topicName=左心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=50dc25016902, createdName=ylz8411, createdTime=Sat Jul 15 08:04:00 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789851, encodeId=1fd81e898515d, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Mon May 01 21:04:00 CST 2017, time=2017-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289294, encodeId=789e1289294b9, content=<a href='/topic/show?id=ede136018b' target=_blank style='color:#2F92EE;'>#BNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3601, encryptionId=ede136018b, topicName=BNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cd0d217, createdName=huiwelcome, createdTime=Tue Nov 01 04:04:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1290333, encodeId=d408129033333, content=<a href='/topic/show?id=f6e513111bc' target=_blank style='color:#2F92EE;'>#NT-proBNP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13111, encryptionId=f6e513111bc, topicName=NT-proBNP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5662228, createdName=mjldent, createdTime=Tue Nov 01 04:04:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1601818, encodeId=d26516018182a, content=<a href='/topic/show?id=2f801469e57' target=_blank style='color:#2F92EE;'>#PRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14697, encryptionId=2f801469e57, topicName=PRO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a60b18898917, createdName=sunylz, createdTime=Tue Nov 01 04:04:00 CST 2016, time=2016-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626821, encodeId=1f541626821a2, content=<a href='/topic/show?id=986a5101e46' target=_blank style='color:#2F92EE;'>#心房#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51017, encryptionId=986a5101e46, topicName=心房)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=20ba21064884, createdName=sodoo, createdTime=Tue Nov 01 04:04:00 CST 2016, time=2016-11-01, status=1, ipAttribution=)]
    2016-11-01 sodoo

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