Nutrients:菊科植物Crassocephalum rabens的提取物可有效改善皮肤老化

2022-08-03 MedSci原创 MedSci原创

皮肤是人体中最大的器官,约占成人总重量的15%,保护人体免受环境的直接影响,并有助于体温调节和渗透调节。使用含有功能成分的化妆品或膳食补充剂已成为减缓皮肤老化和保持良好皮肤状况的流行方式。

皮肤是人体中最大的器官,约占成人总重量的15%,保护人体免受环境的直接影响,并有助于体温调节和渗透调节。使用含有功能成分的化妆品或膳食补充剂已成为减缓皮肤老化和保持良好皮肤状况的流行方式。Crassocephalum rabens(菊科)是一种常见的草药,在台湾民间医学中用于治疗炎症相关的综合症。药理学研究发现,半乳糖脂表现出抗氧化、抗炎和抗透明质酸酶的活性,并改善健康受试者的皮肤皱纹、水分和弹性。然而,C. rabens及其主要活性化合物1,2-di-O-linolenoyl-3-O-β-galactopyranosyl-sn-glycerol(dLGG)的抗衰老作用仍然难以捉摸。近日,发表于Nutrients的一项随机对照试验调查了C. rabens是否能改善健康人的皮肤状况。

研究共纳入40名受试者,随机平均分配到对照组或治疗组,并被要求每天服用安慰剂或C. rabens提取物胶囊,为期一个月。在研究之前和之后都对皮肤参数进行了测量。

 

结果显示,治疗组的皮肤弹性、皱纹、胶原蛋白含量、亮度和水合度在基线和第4周之间有明显差异。特别是,与安慰剂组相比,使用C. rabens提取物治疗后,受试者皮肤皱纹(p < 0.05)、亮度(p < 0.001)、胶原蛋白含量(p < 0.01)和紫外线斑(p < 0.05)都有明显改善。

综上所述,该研究成功地证明了C. rabens在防止皮肤老化方面的应用。然而,考虑到研究设计的局限性,应开展进一步的研究调查,以验证C. rabens和dLGG在啮齿动物和人类中的抗衰老活性。

 

原始出处:

 

Chen-Meng Kuan, et al., Ameliorating Effect of Crassocephalum rabens (Asteraceae) Extract on Skin Aging: A Randomized, Parallel, Double-Blind, and Placebo-Controlled Study. Nutrients. 2022 Jun 27;14(13):2655. doi: 10.3390/nu14132655.

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