Nutrients:口服东亚草药(EAHM)可有效治疗银屑病炎症性皮肤病变

2022-07-27 MedSci原创 MedSci原创

银屑病是一种具有各种临床表现的炎症性自身免疫性皮肤病。近日,发表于Nutrients的一项系统回顾系统地评估口服东亚草药(EAHM)对银屑病炎症性皮肤病变的疗效和安全性,并探索药物研发的核心草药材料。

银屑病是一种具有各种临床表现的炎症性自身免疫性皮肤病。近日,发表于Nutrients的一项系统回顾系统地评估口服东亚草药(EAHM)对银屑病炎症性皮肤病变的疗效和安全性,并探索药物研发的核心草药材料。

研究人员在10个电子数据库中全面搜索了从开始到2021年7月29日的随机对照试验。所见所到的文献存在研究异质性时,通过敏感性分析、荟萃回归和亚组分析确定原因。使用改良的随机试验偏倚风险工具对方法学质量进行了独立评估。

 

结果,共有56项试验,包括4966名银屑病患者符合选择标准。Meta分析结果支持EAHM单药治疗可有效改善牛皮癣面积严重程度指数(PASI)70(RR:1.2845;95%CI:1.906至1.3858,p &lt;0.0001)、PASI 60(RR:1.1923;95%CI:1. 1134至1.2769,p < 0.0001),连续PASI评分(MD:-2.3386,95% CI:-3.3068至-1.3704,p < 0.0001),IL-17、IL-23、TNF-α和皮肤病生活质量指数。接受EAHM单药治疗的患者的不良事件发生率明显降低。此外,根据对该荟萃分析中所包含的草药数据的额外检查,确定了16种核心材料。这些材料的利用方式很接近,而且都具有抗炎特性。

综上所述,该研究的结果支持口服EAHM单药治疗可能会改善银屑病的炎症性皮肤病变。同时,通过对个别药理活性和协同作用的后续研究,已确定的核心材料有望作为有用的候选药物来加以利用。

 

原始出处:

 

Hee-Geun Jo, et al., Oral Administration of East Asian Herbal Medicine for Inflammatory Skin Lesions in Plaque Psoriasis: A Systematic Review, Meta-Analysis, and Exploration of Core Herbal Materials. Nutrients. 2022 Jun 12;14(12):2434. doi: 10.3390/nu14122434.

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    2023-03-13 ms1000000413528422 来自甘肃省
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    2023-01-04 zll0637
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    2022-07-28 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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