JAHA:无诱因静脉血栓栓塞对死亡和主要心血管事件的长期影响如何?

2017-05-04 xing.T MedSci原创

由此可见,这项全国性的队列研究显示无诱因的静脉血栓栓塞的患者,尤其是老年糖尿病男性患者,死亡和心血管事件的风险增加。死亡和主要心血管不良事件的风险在确诊后的第一年内最高,并在后续10年的随访期间会一直持续。

无诱因的静脉血栓栓塞(VTE)患者的死亡率风险增加,但它们的心血管风险是否也有所增加目前仍不清楚。近日,心血管领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在探讨与无诱因的静脉血栓栓塞患者总死亡率和主要心血管不良事件的相关因素。

研究人员在2000年至2013年期间从台湾健康保险数据库中确定了2154例新诊断的无诱因的静脉血栓栓塞患者,不包括那些病因可逆的、潜在癌症的或自身免疫性疾病的患者。这些静脉血栓栓塞患者匹配了4308名年龄、性别和心血管风险相类似的对照者,并进行了比较。


研究人员发现静脉血栓栓塞患者的死亡率和主要不良心血管事件的风险分别增加了2.23倍(95%可信区间为1.93-2.57;P<0.0001)和1.86倍(95%可信区间为1.65-2.09;P<0.0001),明显高于匹配的对照者。这些事件大多发生在无诱因的静脉血栓栓塞诊断后第一年内。在静脉血栓栓塞患者中,高龄、男性和合并糖尿病提示着死亡和主要心血管不良事件发生率较高。相反,伴发高脂血症可以减弱这些风险。

由此可见,这项全国性的队列研究显示无诱因的静脉血栓栓塞的患者,尤其是老年糖尿病男性患者,死亡和心血管事件的风险增加。死亡和主要心血管不良事件的风险在确诊后的第一年内最高,并在后续10年的随访期间会一直持续。

原始出处:

Wei‐Ting Chang, et al. Long‐Term Effects of Unprovoked Venous Thromboembolism on Mortality and Major Cardiovascular Events.JAHA. 2017. https://doi.org/10.1161/JAHA.117.005466

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    2017-12-06 xue8602
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createdTime=Fri May 05 06:32:00 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193929, encodeId=f6501939297d, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri May 05 06:24:54 CST 2017, time=2017-05-05, status=1, ipAttribution=)]
  5. 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createdTime=Fri May 05 06:32:00 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193929, encodeId=f6501939297d, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri May 05 06:24:54 CST 2017, time=2017-05-05, status=1, ipAttribution=)]
    2017-05-06 zhaohui6731
  6. 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  7. 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target=_blank style='color:#2F92EE;'>#主要心血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23271, encryptionId=5ec6232e1bd, topicName=主要心血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=058f14296236, createdName=jiyangfei, createdTime=Sat May 06 12:43:00 CST 2017, time=2017-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=194015, encodeId=80aa194015fe, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo5nmIH5IQqCKjJgSCuicPWUWOUcdqt1ROPnEiaOYN4pSHibDv8la3OxNLalvuvUXn8clpJlrpuyTpckgt9OPkeSSdT/0, createdBy=8fd71930726, createdName=半夏微凉, createdTime=Fri May 05 07:38:29 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193968, encodeId=820019396825, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Fri May 05 06:56:23 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193942, encodeId=f9d719394220, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/udqvoAsWtvRVficPKOpMh4M31O9bJ8jMiaUHAheeNpIqMapC8mUnBWfEskrcVjofbicWU4icRD6vFvVeEYlPmSbXELickazEGVFYO/0, createdBy=24741603767, createdName=医艺依意, createdTime=Fri May 05 06:32:00 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193929, encodeId=f6501939297d, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri May 05 06:24:54 CST 2017, time=2017-05-05, status=1, ipAttribution=)]
    2017-05-05 半夏微凉

    学习了谢谢分享

    0

  8. 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createdTime=Fri May 05 06:32:00 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193929, encodeId=f6501939297d, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri May 05 06:24:54 CST 2017, time=2017-05-05, status=1, ipAttribution=)]
    2017-05-05 飛歌

    学习了很有用

    0

  9. 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createdTime=Fri May 05 06:32:00 CST 2017, time=2017-05-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=193929, encodeId=f6501939297d, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Fri May 05 06:24:54 CST 2017, time=2017-05-05, status=1, ipAttribution=)]
    2017-05-05 医艺依意

    学习了,谢谢分享

    0

  10. 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    2017-05-05 龙胆草

    学习了,谢谢分享

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