Clin Nutr:补充益生菌可降低超重/肥胖个体的体脂和心血管疾病风险标志物

2021-08-08 Nebula MedSci原创

补充益生菌可降低超重/肥胖个体的体脂和心血管疾病风险标志物

有证据表明,肠道微生物群是肥胖和相关代谢紊乱的病理生理学的一个潜在因素。虽然个别随机对照试验(RCT)评估了益生菌对超重和肥胖受试者肥胖和血管疾病(CVD)危险因素的影响,但结果不一。

一项近期发表的系统综述和荟萃分析,评估了补充益生菌对超重和肥胖受试者体重、体脂和CVD风险标志物的影响。

研究人员在MEDLINE(通过PubMed)、EMBASE、Scopus和LILACS数据库中检索了2020年12月前发表的随机对照试验。采用随机效应模型进行了Meta分析,分析联合试验的影响。

益生菌对体重的影响

纳入了26项随机对照试验,共1720位受试者。数据汇总显示,与对照组相比,益生菌在多个方面都有显著效果,包括减肥(MD:-0.70 kg; 95%CI:-1.04~-0.35 kg; P<0.0001)、体重指数(BMI:MD:-0.24 kg/m2; 95%CI:-0.35~-0.12 kg/m2; P=0.0001)、腰围(WC:MD: -1.13 cm; 95%CI: -1.54~-0.73 cm; P<0.0001)、体脂 (MD: -0.71 kg; 95%CI: -1.10~-0.32 kg; P=0.0004)、肿瘤坏死因子-α (MD: -0.16 pg/ml; 95%CI: -0.24~-0.08 pg/ml; P=0.0001)、胰岛素(MD: -0.85mcU/ml; 95%CI: -1.50~-0.21mcU/ml; P=0.010)、胆固醇 (MD: -0.16 mmol/l; 95%CI: -0.26~-0.05 mmol/l; P=0.003)和LDL (MD: -0.09 mmol/l; 95%CI: -0.16~-0.03 mmol/l; P=0.006)。

益生菌对BMI的影响

在使用单菌群和多菌群的研究中,体重、BMI和WC均显著下降。只有在益生菌剂量≥1010 CFU、持续时间≥8周的研究中,才观察到体脂指标的降低

综上所述,该荟萃分析表明,摄入益生菌可能有助于改善超重和肥胖个体的体重、体脂和一些CVD风险标志物

原始出处:

Pontes Karine Scanci da Silva,Guedes Marcella Rodrigues,Cunha Michelle Rabello da et al. Effects of probiotics on body adiposity and cardiovascular risk markers in individuals with overweight and obesity: A systematic review and meta-analysis of randomized controlled trials.[J] .Clin Nutr, 2021, 40: 4915-4931. https://doi.org/10.1016/j.clnu.2021.06.023

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    2021-10-10 赖煜堂

    学习了

    0

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    2021-08-09 ms5000000646734638

    非肥胖症人群使用益生菌是否也有益处呢?

    1

    展开1条回复
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    2021-08-09 顿大侠

    所以我该怎么补充益生菌?

    1

    展开1条回复
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    2021-08-08 14665577m36暂无昵称

    肥胖个体适用

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    2021-08-08 超超爱学习

    学习了

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