IBD:炎症性肠病女性患者剖宫产和阴道分娩后产后感染的风险增加

2022-05-03 xuyihan MedSci原创

炎症性肠病对与孕程和婴儿的健康有不利影响,但比较小。一般来说,患有克罗恩病或溃疡性结肠炎的孕妇85%表现正常,生出先天畸形的婴儿的发生率仅为1%。

炎症性肠病 (IBD) 最常发病于一个人的生育期,因此,了解与分娩方式对于炎症性肠病并发症非常重要。与没有患IBD的女性相比,患有IBD的女性进行剖宫产的次数有所增加。在没有 IBD 的女性中,剖腹产常见的感染性并发症包括伤口感染、子宫内膜炎和尿路感染。在丹麦一项针对一般人群产后 30 天感染的全国性队列研究中,研究人员发现7.6%的剖宫产女性和1.6%的阴道分娩女性出现了伤口感染或泌尿道感染。然而关于IBD女性分娩后感染的数据很少。因此,本项研究的目标是确定剖宫产、正常阴道分娩或阴道助产的有和没有 IBD 的女性的产后 30 天感染并发症。

 

研究人员收集了丹麦国家登记处自从1997年1月1日至2015年12月31日期间分娩活产单胎的妇女的临床资料。然后根据分娩方式评估了患有和不患有 IBD 的女性产后 30 天的母体感染并发症,最后针对多个混杂因素调整了统计模型,以增加结论的可靠性。

 

研究结果显示总共有3255名患有IBD的女性和207608名没有IBD的女性进行了剖腹产手术。在产后30天内,4.5%的IBD女性和3.7%的非IBD女性出现感染性并发症。感染并发症增加包括总体感染(OR,1.83;95%[CI],1.35-2.47)、胃肠道感染(aOR,4.36,95% CI 2.34-8.10)和皮下组织感染(aOR,4.45;95% CI,2.30–8.50)。其他产褥感染、泌尿外科和妇科感染以及其他感染有所增加,但不显着。对于阴道分娩,5771 名 IBD 女性中的 1.6% 和 793110 名无 IBD 女性中的 1.3% 有感染性并发症,胃肠道感染的 aOR 为 3.17(95% CI,1.47-6.85)。

图:炎症性肠病女性患者剖宫产的危险因素分析

 

本项研究结果显示IBD女性患者产后 30 天感染并发症的风险增加。医生应在产后仔细监测患者,以防止这些不良后果的发生。

 

 

原始出处:

Sonia Friedman. Et al. Increased Risk of Postpartum Infections After Caesarian and Vaginal Delivery in Women With Inflammatory Bowel Disease: A Danish Nationwide Cohort Study. Inflammatory Bowel Diseases.2022.

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    2022-05-04 bnurmamat
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    2022-05-04 linlin2312
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