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AJRCCM：赖克方教授课题组发文，首次证实IFN-γ在咳嗽高敏感性中的作用

2018-04-28 薛定谔的猫 中国医学论坛报

咳嗽敏感性机制
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近日，呼吸疾病国家重点实验室赖克方教授课题组邓政博士的研究论文“Interferon-γ Enhances the Cough Reflex Sensitivity via Calcium Influx in Vagal Sensory Neurons”被“American Journal of Respiratory and Critical Care Medicine”正式在接收并在线发表。

近日，呼吸疾病国家重点实验室赖克方教授课题组邓政博士的研究论文“Interferon-γ Enhances the Cough Reflex Sensitivity via Calcium Influx in Vagal Sensory Neurons”被“American Journal of Respiratory and Critical Care Medicine”正式在接收并在线发表。

通过整体豚鼠咳嗽信号分析技术、原代培养大鼠迷走神经元、细胞免疫荧光成像、钙成像技术与膜片钳技术等方法，该研究首次探讨了IFN-γ对咳嗽敏感性的影响及其机制。研究发现IFN-γ吸入可以增加豚鼠咳嗽敏感性，通过JAK/STAT-PKA-AMPA信号通路引起迷走神经元钙离子内流，使膜电位出现去极化改变，从而提高咳嗽敏感性；当膜电位去极化程度达到快钠通道的阈电位时，就会产生动作电位。该动作电位的形成可能与咳嗽反射存在直接联系。

咳嗽敏感性增高是慢性难治性咳嗽的重要病理生理与临床特征，又称咳嗽高敏综合征。目前机制未明，尚无有效的治疗药物。本项研究首次证实IFN-γ在咳嗽敏感性中的作用，进一步阐明了咳嗽高敏感性的分子机制，并有望为慢性难治性咳嗽或咳嗽高敏综合征的治疗提供新的靶点。

原始出处：
Zheng Deng, et al. Interferon-γ Enhances the Cough Reflex Sensitivity via Calcium Influx in Vagal Sensory Neurons. American Journal of Respiratory and Critical Care Medicine. 19 Apr 2018.

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    2019-02-10 isabellayj

    #RCC#

    0

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    2018-08-05 ms9833124466084992

    #首次证实#

    0

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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sat Apr 28 23:28:57 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310191, encodeId=ea0f310191eb, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Apr 28 23:06:28 CST 2018, time=2018-04-28, status=1, ipAttribution=)]
    2018-04-30 1e1b8538m79(暂无匿称)

    不错的文章值得拥有

    0

  4. 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topicId=null, topicList=[TopicDto(id=57534, encryptionId=7ef25e5346b, topicName=敏感性)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJnkE6UvGFfMS41qV0RicWvVTTeLMicqibeZH5GqO4YhNicyl1Y9jFhylIUBn9ntPYy9jhk5hrfic5cRYw/132, createdBy=5f822500020, createdName=ms5236388012055669, createdTime=Mon Apr 30 13:22:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519033, encodeId=662c15190332f, content=<a href='/topic/show?id=ba989452f5' target=_blank style='color:#2F92EE;'>#IFN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9452, encryptionId=ba989452f5, topicName=IFN)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b711235060, createdName=bugit, createdTime=Mon Apr 30 13:22:00 CST 2018, time=2018-04-30, status=1, ipAttribution=), 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310200, encodeId=1308310200e0, content=通过整体豚鼠咳嗽信号分析技术.原代培养大鼠迷走神经元.细胞免疫荧光成像.钙成像技术与膜片钳技术等方法.该研究首次探讨了IFN-γ对咳嗽敏感性的影响及其机制.研究发现IFN-γ吸入可以增加豚鼠咳嗽敏感性.通过JAK/STAT-PKA-AMPA信号通路引起迷走神经元钙离子内流.使膜电位出现去极化改变.从而提高咳嗽敏感性,当膜电位去极化程度达到快钠通道的阈电位时.就会产生动作电位.该动作电位的形成可能与咳嗽反射存在直接联系., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Apr 28 23:55:59 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310196, encodeId=7e383101962f, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sat Apr 28 23:28:57 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310191, encodeId=ea0f310191eb, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Apr 28 23:06:28 CST 2018, time=2018-04-28, status=1, ipAttribution=)]
    2018-04-30 ms5236388012055669

    #敏感性#

    0

  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310200, encodeId=1308310200e0, content=通过整体豚鼠咳嗽信号分析技术.原代培养大鼠迷走神经元.细胞免疫荧光成像.钙成像技术与膜片钳技术等方法.该研究首次探讨了IFN-γ对咳嗽敏感性的影响及其机制.研究发现IFN-γ吸入可以增加豚鼠咳嗽敏感性.通过JAK/STAT-PKA-AMPA信号通路引起迷走神经元钙离子内流.使膜电位出现去极化改变.从而提高咳嗽敏感性,当膜电位去极化程度达到快钠通道的阈电位时.就会产生动作电位.该动作电位的形成可能与咳嗽反射存在直接联系., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Apr 28 23:55:59 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310196, encodeId=7e383101962f, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sat Apr 28 23:28:57 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310191, encodeId=ea0f310191eb, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Apr 28 23:06:28 CST 2018, time=2018-04-28, status=1, ipAttribution=)]
    2018-04-30 bugit

    #IFN#

    0

  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310200, encodeId=1308310200e0, content=通过整体豚鼠咳嗽信号分析技术.原代培养大鼠迷走神经元.细胞免疫荧光成像.钙成像技术与膜片钳技术等方法.该研究首次探讨了IFN-γ对咳嗽敏感性的影响及其机制.研究发现IFN-γ吸入可以增加豚鼠咳嗽敏感性.通过JAK/STAT-PKA-AMPA信号通路引起迷走神经元钙离子内流.使膜电位出现去极化改变.从而提高咳嗽敏感性,当膜电位去极化程度达到快钠通道的阈电位时.就会产生动作电位.该动作电位的形成可能与咳嗽反射存在直接联系., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Apr 28 23:55:59 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310196, encodeId=7e383101962f, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sat Apr 28 23:28:57 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310191, encodeId=ea0f310191eb, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Apr 28 23:06:28 CST 2018, time=2018-04-28, status=1, ipAttribution=)]
    2018-04-29 秀红

    学习了

    0

  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310200, encodeId=1308310200e0, content=通过整体豚鼠咳嗽信号分析技术.原代培养大鼠迷走神经元.细胞免疫荧光成像.钙成像技术与膜片钳技术等方法.该研究首次探讨了IFN-γ对咳嗽敏感性的影响及其机制.研究发现IFN-γ吸入可以增加豚鼠咳嗽敏感性.通过JAK/STAT-PKA-AMPA信号通路引起迷走神经元钙离子内流.使膜电位出现去极化改变.从而提高咳嗽敏感性,当膜电位去极化程度达到快钠通道的阈电位时.就会产生动作电位.该动作电位的形成可能与咳嗽反射存在直接联系., beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sat Apr 28 23:55:59 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310196, encodeId=7e383101962f, content=不错的文章值得拥有, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, 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    2018-04-29 哈哈869

    学了

    0

  8. 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topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=eff51996281, createdName=1e1b8538m79(暂无匿称), createdTime=Sat Apr 28 23:28:57 CST 2018, time=2018-04-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=310191, encodeId=ea0f310191eb, content=不错的文章值得推荐, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sat Apr 28 23:06:28 CST 2018, time=2018-04-28, status=1, ipAttribution=)]
    2018-04-28 有备才能无患

    通过整体豚鼠咳嗽信号分析技术.原代培养大鼠迷走神经元.细胞免疫荧光成像.钙成像技术与膜片钳技术等方法.该研究首次探讨了IFN-γ对咳嗽敏感性的影响及其机制.研究发现IFN-γ吸入可以增加豚鼠咳嗽敏感性.通过JAK/STAT-PKA-AMPA信号通路引起迷走神经元钙离子内流.使膜电位出现去极化改变.从而提高咳嗽敏感性,当膜电位去极化程度达到快钠通道的阈电位时.就会产生动作电位.该动作电位的形成可能与咳嗽反射存在直接联系.

    0

  9. 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    2018-04-28 1e1b8538m79(暂无匿称)

    不错的文章值得拥有

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  10. 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    2018-04-28 131****2916

    不错的文章值得推荐

    0

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咳嗽、喘息别惯性思维 小心忽略这个病

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