HUAN BRAIN MAPPING: 结构连接-功能连接偶联可预测特发性耳鸣患者在声音治疗效果

2022-03-31 MedSci原创 MedSci原创

SC-FC偶联可以作为一种指标,用于预测特发性耳鸣患者在声音治疗前的预后。

耳鸣是在没有任何外部刺激的情况下在耳朵里感觉到的一种幻听。它严重影响患者的生活,并伴有各种问题,如难以集中和倾听、焦虑和抑郁,甚至对患者的家庭、工作表现和社会产生重大影响。因此,迫切需要新的有效甚至个体化的治疗方法。拓扑性质是神经网络的核心,其耦合关系可以反映耳鸣患者不同的治疗效果。

Qian Chen等在HUMAN BRAIN MAPPING杂志发表研究文章,假设耳鸣患者在声音治疗(窄带噪音)后的不同结果会有不同的脑网络拓扑改变。

该研究对60例特发性耳鸣患者和57例健康对照组进行了前瞻性弥散张量成像和静息态功能磁共振成像(fMRI)扫描。对结构连接(SC)、功能连接(FC)以及SC-FC耦合进行了图论网络分析及临床表现和图形理论特征之间的关联分析。

基于脑网络体图谱的脑连接矩阵

治疗有效组(EG组)28例,无效组 (IG) 32例。对于FC, EG组的局部效率高于IG组。

对于SC, EG和IG患者的归一化特征路径长度、特征路径长度和整体效率均低于HC组。

更重要的是,IG组比HC组偶联度更高,而EG组和HC组间偶联度无差异。

功能性和结构性网络连接的小世界性。

此外,在EG患者的SC特征和临床表现之间有显著的相关性。

耳鸣患者的结构网络特性与临床变量之间的相关性。

该研究结果表明,耳鸣患者表现出显著的脑网络拓扑改变,尤其是结构性脑网络。更重要的是,不同疗效的患者表现出明显的SC-FC拓扑耦合特性。SC-FC偶联可以作为一种指标,用于预测特发性耳鸣患者在声音治疗前的预后。

原文出处

Distinct brain structural-functional network topological coupling explains different outcomes in tinnitus patients treated with sound therapy. Qian Chen. First published: 25 March 2022. https://doi.org/10.1002/hbm.25848

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