Otol Neurotol:青少年肥胖是感官性听力损失的独立风险因子

2018-08-26 AlexYang MedSci原创

最近,有研究人员调查验证了儿童肥胖是感光听力损失(SNHL)的一个风险因子,且与其他代谢风险因子无关的假设。研究是一个复杂的、多阶段的、人口区域分层的研究,搜集了来自美国非制度化人口的代表性数据。研究包括了来自NHANES数据库年龄在12到19岁的5638名青少年(2005-2010)。身体质量指数不小于第95个百分位的参与者被定义为肥胖,并在0.5、1和2kHz或者至少一个耳朵在3, 4, 6和

最近,有研究人员调查验证了儿童肥胖是感光听力损失(SNHL)的一个风险因子,且与其他代谢风险因子无关的假设。

研究是一个复杂的、多阶段的、人口区域分层的研究,搜集了来自美国非制度化人口的代表性数据。研究包括了来自NHANES数据库年龄在12到19岁的5638名青少年(2005-2010)。身体质量指数不小于第95个百分位的参与者被定义为肥胖,并在0.5、1和2kHz或者至少一个耳朵在3, 4, 6和8kHz时纯音均值大于15dB HL定义为SNHL。研究人员还利用多变量逻辑回归评估了肥胖患者的听力损失发生率,并与正常体重的参与者进行了比较。多变量模型包括年龄、性别、经济状态、种族、抽烟、高密度脂蛋白水平、甘油三酯水平、提高的血压测量、血红蛋白A1C水平和c反应蛋白水平。研究发现,SNHL的比例在肥胖患者中为21.5%,在正常体重青少年中为13.44%(p<0.0001)。在多变量分析中,肥胖与SNHL风险增加1.73倍相关(95% CI: 1.25-2.40, p=0.006)。潜在的混杂因素和中介因素在肥胖患者的SNHL风险中影响很小(OR:1.69-1.75, 所有p<= 0.01)。

最后,研究人员指出,在青少年中,肥胖与更高的SNHL流行度相关,并且与其他潜在因素相互独立。

原始出处:


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    2018-09-04 荒郊野树

    天咯roll麻婆别个色差额

    0

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    2018-08-28 ysjykql
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  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Aug 26 23:36:16 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341001, encodeId=93903410014a, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Aug 26 23:10:09 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340997, encodeId=ffcc34099edd, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, 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    2018-08-27 huangshang9812

    哈哈哈,学习了

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Aug 26 23:36:16 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341001, encodeId=93903410014a, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Aug 26 23:10:09 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340997, encodeId=ffcc34099edd, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, 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    2018-08-27 flysky120

    现在肥胖的很多,锻炼身体的太少了而且开车的人更减少行走和运动量了

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Aug 26 22:37:08 CST 2018, time=2018-08-26, status=1, ipAttribution=)]
    2018-08-27 太阳系小猪

    肥胖有什么优点吗?目前为止好像没有看到

    0

  8. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Mon Aug 27 09:58:01 CST 2018, time=2018-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341042, encodeId=41da341042d3, content=肥胖有什么优点吗?目前为止好像没有看到, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7e71713450, createdName=太阳系小猪, createdTime=Mon Aug 27 06:55:18 CST 2018, time=2018-08-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341006, encodeId=857234100661, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Aug 26 23:36:16 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341001, encodeId=93903410014a, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Aug 26 23:10:09 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340997, encodeId=ffcc34099edd, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Aug 26 22:37:08 CST 2018, time=2018-08-26, status=1, ipAttribution=)]
    2018-08-26 惠映实验室

    学习了,谢谢分享。

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun Aug 26 23:36:16 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341001, encodeId=93903410014a, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Sun Aug 26 23:10:09 CST 2018, time=2018-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340997, encodeId=ffcc34099edd, content=不错的文章值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04f22055142, createdName=131****2916, createdTime=Sun Aug 26 22:37:08 CST 2018, time=2018-08-26, status=1, ipAttribution=)]
    2018-08-26 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  10. 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    2018-08-26 131****2916

    不错的文章值得推荐一下

    0

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BMC Res Notes:SLC26A4对非综合症语前儿童感官听力损失影响研究

遗传性听力损失(HL)是人类中最常见的感官听力损失。除了GJB2和GJB6基因中的变异之外,在SLC26A4基因中的病理变异已经被报道是遗传性HL的病因之一,并且它主要是在内耳的生理中起作用。最近,有研究人员调查了在非综合症语前儿童感官听力损失巴西患者中SLC26A4基因的变异的流行度。研究人员利用了高分辨率融合技术从与耳聋无关的患者的88个DNA样本中进行了筛选,这些患者值钱不报道在GJB2,

盘点:遗传因子与听力损失

【1】Clin Genet:全外显子组测序在HOMER2中鉴定了常染色体显性非综合征耳聋的一个第二致病变异听力损失在世界范围内是一种常见的感官障碍,并且大约一半的发病都起因于遗传因素。最近,有研究人员在一个患有常染色体显性非综合征听力损失的中国家庭中,在HOMER2中鉴定了一个新的致病变异。研究人员指出,他们的结果是全球范围内第二个由HOMER2中的一个变异引起的听力损失。在该中国家庭中,HO