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Stem cells：年老的造血干细胞可通过与年轻的干细胞相互作用而重返年轻！

2017-12-25 MedSci MedSci原创

造血干细胞间充质干细胞骨髓移植衰老
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在骨髓移植中，供体的年龄是一个重要的关注点，因为年老的造血干细胞（HSCs）移植效率相对较低。研究人员通过小鼠系统发现，年老的HSCs与年幼的间充质干细胞（MSCs）短暂的相互作用，可通过细胞间转移含有自噬相关的mRNAs的微型囊泡（MVs）而使年老的HSCs年轻化、恢复细胞功能，同时MSCs的AKT信号被激活，出现老化。激活的AKT会减少细胞微型囊泡内的自噬相关的mRNAs，并将miR-17和m

在骨髓移植中，供体的年龄是一个重要的关注点，因为年老的造血干细胞（HSCs）移植效率相对较低。

研究人员通过小鼠系统发现，年老的HSCs与年幼的间充质干细胞（MSCs）短暂的相互作用，可通过细胞间转移含有自噬相关的mRNAs的微型囊泡（MVs）而使年老的HSCs年轻化、恢复细胞功能，同时MSCs的AKT信号被激活，出现老化。

激活的AKT会减少细胞微型囊泡内的自噬相关的mRNAs，并将miR-17和miR-34a分割成其外泌体，并将其转移到HSCs，下调其自噬诱导的mRNA。

本研究数据证实了niche介导HSCs老化的过程。抑制年老的MSCs中的AKT可增加其MVs中自噬相关的mRNAs，并可减少其外泌体的miR-17和miR-34a。有趣的是，上述“获救”的MVs的年轻化力量甚至比年轻的MVs的MVs更强。

该研究结果表明，通过HSCs的体外再生技术，提高移植效果，老年人亦可作为骨髓移植的供体，即可大大扩大捐献者人群。

原始出处：


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    2018-04-01 medscijoin

    #相互作用#

    0

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    2018-06-25 hb2008ye

    #stem cell#

    0

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    2018-11-08 yykkxiaodou

    #stem cells#

    0

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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu Jan 04 06:37:27 CST 2018, time=2018-01-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273879, encodeId=d2142e3879cb, content=体外再生技术.提高移植效果.老年人亦可作为骨髓移植的供体, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUlbw1Mf1vppicGcaWPx1YUOgLgKccao77Rykbx3jiazqzwcyXMdzRIZkhFyBPqknibeuOGhXI1VzVg/0, createdBy=7f162154630, createdName=沙漠浪人, createdTime=Sat Dec 30 15:11:33 CST 2017, time=2017-12-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273619, encodeId=a54f2e36197a, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Dec 29 20:06:57 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471567, encodeId=d41714e1567ec, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Wed Dec 27 13:21:00 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614963, encodeId=c465161496378, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Wed Dec 27 13:21:00 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
    2018-03-03 zhaozhouchifen

    #Cell#

    0

  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Dec 29 20:06:57 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471567, encodeId=d41714e1567ec, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Wed Dec 27 13:21:00 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614963, encodeId=c465161496378, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Wed Dec 27 13:21:00 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
    2018-02-09 维他命

    #CEL#

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Dec 29 20:06:57 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471567, encodeId=d41714e1567ec, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Wed Dec 27 13:21:00 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614963, encodeId=c465161496378, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Wed Dec 27 13:21:00 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
    2018-01-04 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Fri Dec 29 20:06:57 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1471567, encodeId=d41714e1567ec, content=<a href='/topic/show?id=c0132410554' target=_blank style='color:#2F92EE;'>#互作#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24105, encryptionId=c0132410554, topicName=互作)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dc87121468, createdName=ylz8405, createdTime=Wed Dec 27 13:21:00 CST 2017, time=2017-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614963, encodeId=c465161496378, content=<a href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Wed Dec 27 13:21:00 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
    2017-12-30 沙漠浪人

    体外再生技术.提高移植效果.老年人亦可作为骨髓移植的供体

    0

  8. 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href='/topic/show?id=d74a44e2e7' target=_blank style='color:#2F92EE;'>#cells#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4472, encryptionId=d74a44e2e7, topicName=cells)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=659819575782, createdName=124988c7m101暂无昵称, createdTime=Wed Dec 27 13:21:00 CST 2017, time=2017-12-27, status=1, ipAttribution=)]
    2017-12-29 三生有幸9135

    学习一下谢谢分享

    0

  9. 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    2017-12-27 ylz8405

    #互作#

    0

  10. 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    2017-12-27 124988c7m101暂无昵称

    #cells#

    0

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