Metabolism:饱和脂肪酸对代谢综合征风险的影响有所差异!

2018-02-03 xing.T MedSci原创

由此可见,SFAs不同碳数已被证明对代谢综合征状况的影响具有差异,提示SFAs的效应并不均一。

近日,代谢性疾病领域权威杂志Metabolism-Clinical and Experimental上发表了一篇研究文章,研究人员旨在调查参加健康体检的台湾人血浆中饱和脂肪酸(SFAs)与代谢综合征风险之间的相关性。

这项病例对照研究是基于1000例代谢综合征患者,并且按1:1匹配对照者(平均年龄为54.9 ± 10.7岁;女性占36%)。代谢综合征是根据国际糖尿病联合会的标准来定义的。研究人员采用气相色谱法测定了血浆中脂肪酸的分布(占总脂肪酸的百分比)。

研究人员发现偶数碳链SFAs,包括14:0、16:0和18:0,与代谢综合征相关;调整后的比值比[OR]、95%可信区间[CI]为3.32,[1.98-5.59];然而,极长链SFAs,包括20:0、21:0、22:0、23:0和24:0,与代谢综合征呈负相关。经调整后的比值比[95%CI]为0.67[0.58-0.78]。受试者操作特性曲线下面积从基础模型的0.814,在添加了奇数碳链、偶数碳链和极长链SFAs后分别增加至0.815(P=0.54,与基础模型相比)、0.818(P<0.0001)和0.820(P<0.0001)。基于12项研究的荟萃分析显示最高与最低SFAs水平的患者相比,2型糖尿病合并的风险比为1.16[0.96-1.41]。

由此可见,SFAs不同碳数已被证明对代谢综合征状况的影响具有差异,提示SFAs的效应并不均一。

原始出处:

Wei-Sin Yang,et al. Differential effects of saturated fatty acids on the risk of metabolic syndrome: a matched case-control and meta-analysis study.Metabolism-Clinical and Experimental.2018. https://doi.org/10.1016/j.metabol.2018.01.006

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    2018-08-26 一闲
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    2018-04-12 guojianrong
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    2018-02-05 闆锋旦
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    2018-02-03 131****1460

    学习了受益匪浅

    0

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    2018-02-03 1e0f8808m18(暂无匿称)

    好文章.学习了.

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